Renal scarring and osteopontin gene C/T polymorphism in children with primary vesicoureteral reflux.
نویسندگان
چکیده
We examined for osteopontin (OPN) gene C/T polymorphism in 78 patients (53 girls) with vesicoureteric reflux, with or without renal scarring. The T allele frequency was associated with a significantly increased risk (26.4 fold) of renal scarring.
منابع مشابه
Primary Vesicoureteral Reflux in Children in Southern Iran
Background: Experience with vesicoureteral reflux (VUR) differs in different centers and there is plenty of controversies.Objective: To evaluate the outcome of primary VUR complications and the rate of recurrence of UTI.Methods: In a retrospective study, the medical charts of all infants and children with primary VUR who were followed up by one nephrologist were reviewed. During 16 years, 271...
متن کاملPrevalence of GNB3 C825T Gene Polymorphism in Children with Vesicoureteral Reflux in Kerman
Background & Aims: Vesicoureteral Reflux (VUR) is a congenital defect of the urinary tract which has been reported in approximately 1% of children. Several immunological and genetic factors are listed as major causes of this problem. The C825T polymorphism of the GNB3 gene is among the genetic factors that may be involved in the development or progression of the disease. Participatory role o...
متن کاملPRIMARY VESICOURETERAL REFLUX IN IRANIAN CHILDREN: A FOLLOW-UP OF 330 CASES
ABSTRACT Background: Experience with vesicoureteral reflux (VUR) differs in different centers and there are plenty of controversies. The aim of this study was to evaluate the outcome of primary VUR complications and the rate of recurrence of UTI. Methods: The medical charts of all infants and children with primary VUR who were followed up by two nephrologists were reviewed. During 19 years (19...
متن کامل[Renal scars in children with primary vesicoureteral reflux].
OBJECTIVE To determine the incidence of renal scars in children with primary vesicoureteral reflux taking into consideration the following variables: sex, age at diagnosis, febrile urinary infection, degree of reflux and bacteria specimen. METHOD Retrospective study of 58 children with age ranging from 2 months to 11 years, presenting primary vesicoureteral reflux detected by voiding cystoure...
متن کاملAbnormal renal scans and decreased early resolution of low grade vesicoureteral reflux.
PURPOSE Limited studies suggest a relationship between scarring on renal scan and failure to resolve vesicoureteral reflux. We evaluated the impact of abnormal renal scans on early vesicoureteral reflux resolution. MATERIALS AND METHODS The medical records and renal scans were reviewed of children diagnosed with primary reflux between 1988 and 2004. We defined an abnormal renal scan as renal ...
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ورودعنوان ژورنال:
- Indian pediatrics
دوره 49 4 شماره
صفحات -
تاریخ انتشار 2012